Impact Factor
(JCR 2021)
1.564
Recent Publications
Calendula glycolic extract enhances wound healing of alginate hydrogel
Possa, Gisele De Oliveira Krubniki; Chopek, Solange; Pereira, Airton Vicente; Koga, Adriana Yuriko; Oliveira, Marcia Regina Paes De; Costa, Michele Dietrich Moura; ABSTRACT Purpose: To assess the cytotoxicity and wound healing properties of an alginate hydrogel containing calendula glycolic extract. Methods: Cell viability in murine fibroblasts (3T3 cells) was evaluated using MTT and SRB assays. The wound healing effect was tested in an incisional wound model on 50 female Wistar
Effects and mechanisms of Salvia miltiorrhiza Bunge extract on myocardial cell apoptosis in rat heart failure model
Yang, Xiaofang; Zheng, Xuebin; Xiao, Xiangqian; Li, Li; ABSTRACT Purpose: This work aimed to investigate the effects of Tanshinone IIA (Tan IIA) on myocardial cell (MC) apoptosis in a rat model of heart failure (HF). Methods: Tan IIA was extracted from Salvia miltiorrhiza Bunge (SMB) using an ethanol reflux method. Fifty rats were randomly divided into five groups: sham (no treatment), mod (HF model establishment), low dose (LD: 0.1 mL/kg
Effects of ozone therapy applied topically, by bagging, or both on the healing of clean wounds induced in rat’s skin
Frezza, Bárbara Di Martino; Rahal, Sheila Canevese; Santos, Ivan Felismino Charas Dos; Silva, Bruna Martins Da; Silva Junior, José Ivaldo De Siqueira; Ferreira, Gustavo Manea; Vettorato, Michel De Campos; Fogaça, Jéssica Leite; Tsunemi, Miriam Harumi; Fonseca-Alves, Carlos Eduardo; Pellizzon, Claudia Helena; Rosa, Vinicius Dos Santos; ABSTRACT Purpose: This study aimed to evaluate the effects of ozone therapy applied topically and/or by bagging on the healing of clean wounds induced in
Latest news
The result of an experiment with rats brings histopathological and biochemical analysis focusing on the antifibrotic action of PEG 3350 in the case of liver injury induced by MTX and reveals the potential of polyethylene glycol in the fight against hepatotoxicity also caused by other substances that lead to oxidative stress of liver cells.
A drug used for the treatment of epilepsy it has demonstrated epigenetic properties, raising the possibility of use as an adjuvant, associated with chemo and radiotherapy for the treatment of tumors. A study with rats analyzed the inflammatory reaction, angiogenesis and collagen synthesis obtained from oral treatment in a skin lesion model.
By exploring the influence of milk fat globule protein - factor 8 (MFGE8), also known as lactaderin, results obtained through the RhoA/ROCK signaling pathway in an experiment with Sprague Dawley rats point to a decrease in oxidative stress and the inflammatory process, minimizing the impacts caused by trauma by protecting and restoring the barrier function of the intestinal mucosa.
In search of new alternatives for the treatment of portal hypertension, Brazilian researchers develop a pioneering study to validate a model in medium-sized animals, obtaining significant results for the improvement of the techniques applied in cases of gastrointestinal hemorrhage and indicating the direction for advances in diagnostic and therapeutic procedures.
Timeline
17 Sep 1987
SOBRADPEC installation
1989
I Congresso Nacional de Cirurgia Experimental - Maceió/AL
1991
II Congresso Nacional de Cirurgia Experimental - Foz do Iguaçu/PR
17 Sep 1997
SOBRADPEC turns 10 years old
