Impact Factor
(JCR 2021)
1.564
Recent Publications
Repair methods in peripheral nerves after traumatic injuries: a systematic literature review
Costa, Naely Nobre
Costa, Naely Nobre; Santos, Jennifer Ferreira Dos; Aranha, Maria Fernanda De Almeida Cavalcante; Coelho, Erik William Farias; Paes, Victor Leno Silva; Oliveira, Rita De Cássia Silva De; ABSTRACT Purpose: To identify and describe the most used surgical repair methods for traumatic injuries to peripheral nerves, as well as highlight the causes of trauma to peripheral nerves and the most prevalent traumatized nerves. Methods: This is a systematic literature review using
Hypothalamic ghrelin receptors, weight loss, and glycemia in an experimentally induced obesity model treated by sleeve gastrectomy
Ferreira, Claudia Gissi da Rocha
Ferreira, Claudia Gissi Da Rocha; Ribeiro, André Richter; Finck, Christiane Madrid; Percicote, Ana Paula; Matias, Jorge Eduardo Fouto; ABSTRACT Purpose: Body weight, blood glucose, and hypothalamic ghrelin receptors were monitored in an animal model of obesity after being treated with sleeve gastrectomy. Methods: Forty-two adult male Wistar rats were randomized into two groups: a non-obese group (standard chow); and an obese group, in which obesity was induced by feeding liquid
Dose-dependent protective profile of trans-anethole in experimental traumatic brain injury in mice via modulation of apoptotic and inflammatory protein expression, and oxidative stress
Çevik, Aziz
Çevik, Aziz; Atlas, Burak; Erdoğan, Gamze; Atama, Mehmet Salih; Altun, Barış; Yılmaz, Tevfik; ABSTRACT Purpose: To investigate the protective effect of trans-anethole in experimental traumatic brain injury (TBI) in mice. Methods: Thirty-five adult mice were divided into five groups (control, TBI, TBI+A40, TBI+A80, and TBI+A160). No treatment was performed in the control group. The treated groups (TBI+A40, TBI+A80, and TBI+A160) received 40, 80 or 160 mg/kg trans-anethole treatment, respectively. At
Activation of AMPK/OPA1 pathway alleviates traumatic brain damage by regulating mitophagy
Wei, Hao
Wei, Hao; Liao, Jiushan; Gao, Wei; He, Xiangzhong; ABSTRACT Purpose: Mitophagy is an important process in brain damage, and the precise impact on a traumatic brain injury (TBI) model remains unclear. AMP-activated protein kinase (AMPK) regulates mitochondrial homeostasis and mitophagy, which are closely related to the remission of early brain injury. This study sought to explore the mechanism behind AMPK/optic atrophy 1 (OPA1) pathway in TBI via experimental verifications. Methods:
The comparison of the applicability of low-frequency laser, β-tricalcium phosphate, platelet-rich fibrin, and bone marrow in the treatment of tibial fractures in rabbits
Alpman, Umut
Alpman, Umut; Atalan, Gultekin; Karaca, Efe; Perk, Gokcen; ABSTRACT Purpose: To compare and evaluate the radiologic, clinical, and histopathologic results of the treatment methods applied in diaphyseal tibial fractures. Methods: A complete tibial fracture was created in the tibial diaphysis in each rabbit. Experimentally generated fracture fragments were fixed by intramedullary pinning. In the control group (group I), the bone fracture area was left to heal without any treatment technique.
Factors associated with recurrence in operable breast cancer patients undergoing surgery as the sole treatment modality
Bonissoni, Maressa Daniela Anghinoni
Bonissoni, Maressa Daniela Anghinoni; Alves, Fernanda Mara; Almeida, Rafaella Frederico; Smaniotto, Lucca; Berny, Maria Paula De Andrade; Silva, Victor Pereira Da; Fiuza, Brenda Stephanie; Rodrigues, Guilherme Cirino; Neres, Eloisa Maria; Kern, Rodrigo; Santos, Carlos Victor Pereira Dos; Souza, Janoário Athanazio De; Rech, Daniel; Panis, Carolina; ABSTRACT Purpose: Approximately 10% of breast cancer patients with localized operable disease experience recurrence. This study aimed to evaluate patients with early-stage breast cancer (TNM
Comparative analysis of unilateral inguinal hernia repair using Lichtenstein and Prolene hernia system techniques in a public teaching hospital: a retrospective cohort study
Muniz, Lorena
Muniz, Lorena; Santos, Thiago Henrique Dos; Santos, Isabela Silva Dos; Cremon, Bruna Garrido; Salgado Junior, Wilson; ABSTRACT Purpose: To compare early- and medium-term postoperative outcomes of unilateral inguinal hernia repair performed using the Lichtenstein and Prolene hernia system (PHS) techniques in a public teaching hospital. Methods: A retrospective analysis of 897 patients undergoing primary unilateral inguinal hernioplasty (406 with Lichtenstein and 491 with PHS) from January 2011 to March 2025
Study of the enteric and motor inervation, pelvic musculature, and alterations in the sacral region of rat fetuses with ethylenethiourea-induced anorectal anomaly
Oliveira, Evandro Luis da Cunha
Oliveira, Evandro Luis Da Cunha; Vicente, Yvone Avalone De Moraes Villela De Andrade; ABSTRACT Purpose: The aims of this work were to induce anorectal anomaly in rat fetuses via the planned administration of ethylenethiourea (ETU), and to study fetuses exhibiting anorectal malformation, as well as apparently normal fetuses submitted to the effect of ETU. Methods: Time-mated pregnant Wistar rats were randomly divided into control and experimental groups. On gestational day
Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice
Costa, Juliana Dantas da
Costa, Juliana Dantas Da; Araújo, Erika Iara De Souza; Castro, Juan Feliphe Silva De; Costa, Tamiris Bezerra; Luz, Érika Patrícia Chagas Gomes; Vieira, Rodrigo Silveira; Castro-Silva, Igor Iuco; ABSTRACT Purpose: To evaluate membranes originating from pure or oxidized bacterial cellulose (BC)/alginate/strontium apatite hydrogels regarding toxicity, biocompatibility, biodegradation and metabolism. Methods: The toxicity was measured by incubating the materials with Artemia salina for 24 h, and mortality and the 50% lethal
Latest news
The result of an experiment with rats brings histopathological and biochemical analysis focusing on the antifibrotic action of PEG 3350 in the case of liver injury induced by MTX and reveals the potential of polyethylene glycol in the fight against hepatotoxicity also caused by other substances that lead to oxidative stress of liver cells.
A drug used for the treatment of epilepsy it has demonstrated epigenetic properties, raising the possibility of use as an adjuvant, associated with chemo and radiotherapy for the treatment of tumors. A study with rats analyzed the inflammatory reaction, angiogenesis and collagen synthesis obtained from oral treatment in a skin lesion model.
By exploring the influence of milk fat globule protein - factor 8 (MFGE8), also known as lactaderin, results obtained through the RhoA/ROCK signaling pathway in an experiment with Sprague Dawley rats point to a decrease in oxidative stress and the inflammatory process, minimizing the impacts caused by trauma by protecting and restoring the barrier function of the intestinal mucosa.
In search of new alternatives for the treatment of portal hypertension, Brazilian researchers develop a pioneering study to validate a model in medium-sized animals, obtaining significant results for the improvement of the techniques applied in cases of gastrointestinal hemorrhage and indicating the direction for advances in diagnostic and therapeutic procedures.
Timeline
17 Sep 1987
SOBRADPEC installation
1989
I Congresso Nacional de Cirurgia Experimental - Maceió/AL
1991
II Congresso Nacional de Cirurgia Experimental - Foz do Iguaçu/PR
17 Sep 1997
SOBRADPEC turns 10 years old