Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia - Online version e-ISSN: 1678-2674


Downregulation of the high-mobility protein HMGB1 (amphoterin) induced by overexpression of MFGE8 (lactaderin) improves the prognosis of blunt abdominal injury

By exploring the influence of milk fat globule protein – factor 8 (MFGE8), also known as lactaderin, results obtained through the RhoA/ROCK signaling pathway in an experiment with Sprague Dawley rats point to a decrease in oxidative stress and the inflammatory process, minimizing the impacts caused by trauma by protecting and restoring the barrier function of the intestinal mucosa.